Why Canaglu and Farxiga are not suitable for treating obesity
カナグルやフォシーガなどのSGLT2阻害剤は、主に糖尿病治療において重要な役割を果たします。特に、HbA1cが7%以上の高血糖状態にある糖尿病患者に対して有効です。
糖尿病治療における効果：
◦腎臓の働きを調整し、余分なブドウ糖を尿として体外に排出することで、血糖値を下げます。
◦1日に約400kcalのエネルギーを排出し、血糖値の低下と体重減少を促します。
心不全治療における効果：
◦SGLT2阻害剤は心不全の治療薬としても利用可能です
SGLT2 inhibitors are drugs for diabetes patients with hyperglycemia, and it is not appropriate for healthy people to use them for dieting purposes. The reasons why Canaglu and Forxiga are not suitable for dieting are as follows.
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Effects of use in healthy individuals:
When used by healthy individuals with HbA1c levels of around 6% or 5%, appetite may increase to compensate for the loss of energy, leading to overeating. Improper use may lead to weight gain and health problems.
Increased Appetite:
Because SGLT2 inhibitors lower blood sugar levels, the body feels a lack of energy and has a strong desire to consume carbohydrates. This feeling of carbohydrate depletion can lead to a tendency to consume a lot of carbohydrates at meals and snacks, resulting in excess calories.
Metabolic Adaptations:
The body may adjust its metabolism to compensate for lost energy, increasing appetite and/or reducing energy expenditure. This "metabolic adaptation" may result in failure to lose weight with SGLT2 inhibitors.
Risk of Side Effects:
Healthy people are at increased risk of side effects when using it, including dehydration, hypoglycemia, and genital infections.
Misconceptions about increased ketone bodies:
SGLT2 inhibitors increase ketone bodies and can elevate mood, but this feeling of euphoria does not last long and can easily be mistaken for a weight loss effect.
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