What is the GIP/GLP-1 receptor agonist " Zepbound"?
Zepbound was developed as a treatment for type 2 diabetes. It was approved by the US FDA as the diabetes treatment "Mounjaro" in 2022, and then its weight loss effect was evaluated, and it was approved by the US FDA as the obesity treatment "Zepbound" in 2023. By enhancing the action of both GIP and GLP-1, it has been reported that it has a higher weight loss effect than conventional GLP-1-only drugs. Therefore, it has become a new option in the treatment of obesity.
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Active ingredient: Tirzepatide
Tirzepatide is a new type of drug that acts on both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).
Mechanism of action
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appetite suppression
How GIP works
GIP promotes the secretion of insulin (a hormone that lowers blood sugar levels) in response to increases in blood sugar levels, resulting in a feeling of fullness after a meal. Because the appetite suppressant effect of GIP alone is relatively weak, it is further enhanced when combined with the action of GLP-1.Function of GLP-1
GLP-1 acts on the brain's satiety center and has a powerful effect of suppressing appetite.
Blood sugar control
How GIP works
It stabilizes blood sugar levels by promoting the secretion of insulin according to post-meal blood sugar levels. It also moderately regulates the secretion of glucagon (a hormone that raises blood sugar levels), creating a state in which blood sugar levels are less likely to rise sharply.Function of GLP-1
GLP-1 also promotes insulin secretion and suppresses glucagon secretion, improving blood sugar control.
Slows digestion in the stomach
How GIP works
The effect of GIP on the gastrointestinal tract is relatively weak and it is not thought to significantly alter gastric motility.Function of GLP-1
GLP-1 slows down stomach activity and helps you feel fuller longer after a meal, which naturally reduces the amount of food you eat.
How to use Zepp Bound and precautions
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How to use
Zepbound is a self-injection drug that you administer once a week to your stomach, thighs,
It is administered subcutaneously in the arm or elsewhere on the same day each week, starting with a low dose and gradually increasing it so that your body can get used to it.
Points to note
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Use on a set schedule
Injecting on the same day each week will ensure consistent results.
If you miss a shot, give it as soon as possible, but only if there are more than 48 hours until your next scheduled shot.
Be aware of side effects
You may experience nausea or stomach upset, but this will usually improve as your body gets used to it. If your appetite is too low, do not force yourself to eat, but eat small amounts at a time.
Adjust your diet
Avoiding high-fat and high-calorie meals can help reduce side effects. Drink plenty of fluids and eat a balanced diet.
Be aware of chronic illnesses and interactions with other medications
If you have diabetes or a digestive system disease, or are pregnant, you should consult with your doctor. If you take this medicine in combination with other medicines, the side effects may be intensified, so be sure to check beforehand.
Zepbound is an effective drug for weight loss and blood sugar control if used correctly. It is important to continue taking it as directed by your doctor within your limits.
The difference between Saxenda and Zeppbound
サクセンダとゼップバウンドは、どちらも肥満治療のための注射薬ですが、それぞれの作用の仕組みや効果には違いがあります。
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Saxenda:
The active ingredient is liraglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist that regulates blood sugar levels and suppresses appetite.
Zepbound:
The active ingredient is Tirzepatide. It is a "dual agonist" that acts on the GLP-1 receptor as well as the GIP (glucose-dependent insulinotropic polypeptide) receptor. This dual action
It's a big difference.
Indications
Saxenda:
It is approved for the treatment of obesity.
The target population is adults with a BMI of 27 or higher who are overweight (obese), or who have a weight-related health problem (such as high blood pressure or type 2 diabetes).
Zepbound:
It is also approved for the treatment of obesity, but like Saxenda, it is only approved for adults who meet the BMI criteria (30 or higher, or 27 or higher with comorbidities).
However, Zepbound is a newer drug that has been reported to have stronger weight loss effects.
Mechanism of action
Saxenda:
It only stimulates the GLP-1 receptor, suppresses appetite and slows gastric emptying.
This promotes weight loss. It also has the effect of regulating blood sugar levels, but its main purpose is to treat obesity.
Zepbound:
It acts on both GLP-1 and GIP receptors. The additive effect of GIP is
It is expected to improve insulin sensitivity and promote fat breakdown, and has a stronger appetite suppressant effect than Saxenda.
Method of administration
Saxenda:
It is administered subcutaneously once a day. Start with a low dose and gradually increase it to balance the effectiveness and side effects.
Zepbound:
It is administered subcutaneously once a week. The administration frequency is low, so the burden on the patient is minimal.
effect
Saxenda:
Clinical trials have shown that the weight loss effect is about 5-10% on average. Although the effect varies from person to person, it is characterized by moderate weight loss.
Zepbound:
Clinical trials have shown that it reduces body weight by an average of 15-20% or more, and that it is more effective than Saxenda. This is due to the strong action of the dual agonist.
side effects
Gastrointestinal side effects such as nausea, vomiting, and diarrhea are common with both drugs.
However, because Zepbound has a stronger effect, it may cause stronger side effects. On the other hand, Saxenda is administered once a day, so the patient can gradually become accustomed to it, which may reduce side effects.
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Both medications can be used more effectively in combination with diet and lifestyle changes to help you lose weight. It is important to work with your doctor to choose the treatment that is best for you, based on your weight loss goals, your need for glycemic control, your tolerance for side effects, and your preferred dosing frequency.
Who is Zepbound suitable for?
Zepbound is a drug suitable for people who want to lose weight or control their blood sugar levels. It is especially recommended for the following people:
People who want to diet but have difficulty controlling their appetite
This is perfect for people who want to eat less but end up overeating. Zepbound naturally suppresses your appetite, so you can reduce calories without any effort.
People who can't lose weight no matter what they do
It is also effective for people who say, "Even if I exercise and restrict my diet, I can't lose weight..." Zepbound helps burn fat and makes it easier to lose weight.
People at risk for health problems due to obesity
Obesity increases the risk of diabetes, high blood pressure, heart disease, etc. By using Zepp Bound, you can expect to manage your weight properly.
People who want to improve their lifestyle
By using Zepp Bound and reviewing your diet and exercise habits,
It is also suitable for those who want to live a healthier lifestyle as it allows you to lose weight more effectively.
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*People like this should be careful!
Pregnant and breastfeeding women
Those with gastrointestinal disorders (side effects may include stomach upset or nausea)
Those taking other medicines (depending on the combination, side effects may become stronger)
Those with severe digestive disorders (the drug has the effect of slowing down stomach movements, which may worsen symptoms)
Those with a history of pancreatitis (GLP-1 receptor agonists may increase the risk of pancreatitis)
Those with a family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (MEN2) (animal studies suggest an increased risk of thyroid tumors)
Those taking medication for diabetes (which may cause hypoglycemia)
Those with chronic kidney or liver disease (which may affect the metabolism or excretion of the drug)
People with low blood pressure (blood pressure may fall further due to reduced food intake or dehydration)
Elderly people (side effects are more likely to occur and the burden on the body may be greater)
Those who have experienced strong side effects from GLP-1 receptor agonists in the past (Zepbound has a similar effect, so caution is required )
Zepbound helps regulate your food intake and aids in proper weight management
It's possible. If you're interested, talk to your doctor!